Pioneering C3P3 tools for bioproduction

The yields or titers of many recombinant proteins or viruses produced with standard expression systems remain a major hurdle for the development of human therapeutics. Based on its C3P3 technology, Eukarÿs develops radically novel tools for greater bioproduction yields


The Concepts

The bioproduction tools developed by Eukarÿs consist of mammalian cell lines that stably express the C3P3 enzyme and specific plasmids optimized for the C3P3 expression system.

These artificial expression systems allow the production of high yields of recombinant proteins or viruses.

Pros of C3P3 expression system:

  • Reduces timelines and accelerate decision-making using immediately available C3P3 bioproduction tools requiring minimal optimization efforts
  • Increases performances by ~5 fold for recombinant proteins in comparison to transient expression – up to 100-fold greater titers of recombinant orthoreoviruses in comparison to existing technologies were also obtained
  • Reduces the needs of bioproduction capacities, cell culture volume and amounts of reagents
  • Does not alter cell translation and thereby recombinant protein characteristics